I only play classes that don't have to aim. Currently I am using a shotgun that I have to reload after every shot. But with a full stack of anarchy I can kill just about anything in one hit. Though I end up running up to things and pulling the trigger. It's quite a silly strategy, but fun.
Wasn't that one of the big selling points of the Mechromancer? You could run and spray and have fun, and not have to worry about typical FPS fiddlyness, especially when playing co-op.
I'm not a terribly good shot with my Assassin, but I'm getting a lot of use out of melee and Decepti0n. I'm looking for chances to get close and shank dudes. It tends to be a self-destructive strategy, but as long as you take out a few opponents before you die, you're making progress!
I've been playing with a blood soaked shields build, and an amp shield, so every kill I go back to full shield strength and if i manage to get to something without getting them shredded I do a bit of extra damage.
Indeed, that's the only way I can hit anything when I'm not using a shotgun! Kinda reminds me of the scene from the Fifth Element, where Zorg is demonstrating his fancy gun, spraying bullets all over the place and they all go right in the target!
I see someone else has been Vault hunting! I really should attempt to draw a zebra or two myself. You do such a great job with them, as always (and I can even tell which class she is just from the lunchbox).